منابع مشابه
Advances in Scarless Wound Healing
Wound care is a perennial burden for the US healthcare system, costing an estimated $25 billion annually for the treatment of chronic wounds alone [1]. Problems surrounding scarring have also created a $12 billion market annually for treatment [2]. In the 1979 landmark study, Rowlatt et al. reported that human fetal wound healing did not cause scar formation [3]. Animal models were subsequently...
متن کاملScarless wound healing in the mammalian fetus.
Fetal wound healing is a remarkable process that is fundamentally different than postnatal healing. Healing of primarily closed, linear wounds occurs rapidly and without scarring. In late gestational age fetal sheep, a transition to adult-like healing occurs as evidenced by minimal scar formation. Acute inflammation is not involved, fibroblast recruitment and proliferation is minimal, the matri...
متن کاملCellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar ...
متن کاملTowards Scarless Wound Healing: A Comparison of Protein Expression between Human, Adult and Foetal Fibroblasts
Proteins from human adult and foetal fibroblast cell lines were compared, focusing on those involved in wound healing. Proteins were separated through two-dimensional gel electrophoresis (2DE). Differences in protein spot intensity between the lineages were quantified through 3D gel scanning densitometry. Selected protein spots were excised, subjected to tryptic digests, prior to separation usi...
متن کاملThe Biology of Scarless Fetal Wound Repair
Background Data Fetal skin wound healing is characterized by the absence of scar tissue formation. This unique repair process is not dependent on the sterile, aqueous intrauterine environment. The differences between fetal and adult skin wound healing appear to reflect processes intrinsic to fetal tissue, such as the unique fetal fibroblasts, a more rapid and ordered deposition and turnover of ...
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ژورنال
عنوان ژورنال: The Journal of the American College of Certified Wound Specialists
سال: 2010
ISSN: 1876-4983
DOI: 10.1016/j.jcws.2010.05.001